Category Alzheimer’s Disease

Part 3: Xenon’s Neuroprotective and Anti-Inflammatory Effects in Tau-Based Disease 

Tau protein tangles in Alzheimer's disease

Beyond the Plaques: Can We Protect the Brain Even When We Can’t Clear the Pathology? When we think about neurodegenerative diseases, it’s easy to focus on protein aggregates like tau tangles. But here’s the thing: these aggregates aren’t the whole story. What really determines how quickly a patient’s condition worsens isoften the brain’s inflammatory response itself. Think of it this way. Once inflammation kicks into high gear, microglia and astrocytes become chronically activated,synaptic connections start disappearing, and neurons progressively die off. This…

Xenon Reshapes Brain Immune Cells Through IFN-γ Signaling

Microglia phenotype

Introduction Alzheimer’s disease affects over 50 million people worldwide, with projections reaching 150 million by 2050. Current FDA-approved antiamyloid antibody treatments offer only modest effects in slowing disease progression during mild dementia stages, highlighting the need for therapeutic approaches that…